DNAmod: uracil-5-carboxylic acid

Chemical properties

Chemical formula	Net charge	Average mass
C5H4N2O4, C5H4N2O4	0	156.09630

uracil-5-carboxylic acid

Recommended notation

Name	5-carboxyluracil
Abbreviation	5caU
Symbol	b

Nomenclature

IUPAC	SMILES	InChI	InChIKey	Synonyms
2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid	OC(=O)c1c[nH]c(=O)[nH]c1=O	InChI=1S/C5H4N2O4/c8-3-2(4(9)10)1-6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)	ZXYAAVBXHKCJJB-UHFFFAOYSA-N	isoorotic acid uracil 5-carboxylic acid 2,4-dihydroxy-5-pyrimidinecarboxylic acid uracil 5-carboxylate steviolbioside 5-carboxyuracil

Mapping techniques

Method	Method detail	Resolution	Qualifier	References
SMRT	direct detection	single-base		Pais, JE, et al. 2015. Biochemical characterization of a Naegleria TET-like oxygenase and its application in single molecule sequencing of 5-methylcytosine. Proceedings of the National Academy of Sciences of the United States of America. 112(14).

Nature

Origin	Function	Functional detail	Organisms	References
natural	demethylation intermediate		Rattus norvegicus	Patel, JP, et al. 2015. Measurement of Postreplicative DNA Metabolism and Damage in the Rodent Brain. Chemical Research in Toxicology. 28(12).

Database references:

CHEBI:17477

Citations

Pais, JE, et al. 2015. Biochemical characterization of a Naegleria TET-like oxygenase and its application in single molecule sequencing of 5-methylcytosine. Proceedings of the National Academy of Sciences of the United States of America. 112(14).
Patel, JP, et al. 2015. Measurement of Postreplicative DNA Metabolism and Damage in the Rodent Brain. Chemical Research in Toxicology. 28(12).